Double salt of ferric chlorid and cotarnin hydrochlorate and process of making same.



-with chlorid of gold.

UNITED STATES IZLATENT OFFICE.

ARNOLD VOSWI NKEL,

OF GERMANY.

DUiJBLE SALT OF FERRIC CHLORID AND COTARNIN HYDROCflLilFi/lTEAND PROCESSOF MAKING SAME.

Specification of Letters Patent.

Patented Oct. 24, 1905.

Application filed November 28, 1904. Serial No. 234;,6'79. (Specimens)To all 1071,0111 7115 111/117 concern:

Be it known that I, ARNOLD VoswINKEL, apothecary and doctor ofphilosophy, a subj ect of the German Emperor, residing at 154Kurfiirstenstrasse, in the city of Berlin, Kingdom of Prussia, GermanEmpire, have invented a certain new and useful Double Salt of FerricChlorid and Cotarnin. Hydrochlorate and Process of Making the Same, ofwhich the following is a specification.

In scientific literature double salts from metal salts and cotarninhydrochlorate are already described, such as mercuri-chloridcotarninhydrochlorate, platinum chloridcotarnin-hydrochlorate, and the doublesalt (See Gmelin-Kraut, H andtuch der Organischen Ohemie, fourthedition, Vol. 4, second part, 1866, page 1068.) In the same passageBlyth has pointed out that ferric-oxid salts are not colored bycotarnin. Now I have found that chlorid of iron is particularly distinuished by its property of forming a very we crystallized double saltwith cotarnin hydrochlorate, which double salt is to be regarded as acombination of one molecule chlorid of iron and two molecules ofcotarnin hydrochlorate and the formula of which may be thus described:Fe Ch w Il NO cl), In order to manufacture this product two hundred andeighty-five grams of cotarnin are dissolved in 2.5 kilograms of absolutealcohol by the assistance of three hundred and sixty grams hydrochloricacid of twenty-fiveper-cent. strength. Then this solution is dilutedwith six hundred and seventy-five grams of a solution of chlorid of ironof 1.280 specific gravity and 2.5 kilograms absolute alcohol. Bothsolutions are mixed. After a short time the product of the reaction willseparate out as delicate orange -colored leaves, which when they areleft for some time in the liquid will coalesce, so as to form compactruby colored crystallic masses. 'I he double salt is separated from themotherliquor, washed with alcoholether, and is then dried. The compoundmelts at 104 to 105 centigrade, its proportion of iron being, computedat Fe, 13.40 per cent. and being found by actual analysis to be 13.466per 1 cent. in one instance and 13.478 per cent. in another instance. Itdissolves readily in water and in dilute alcohol and more dilficultly inabsolute alcohol. In other it is almost insoluble. If the aqueoussolution is heated for from one to two hours up to the composed and arust'brown precipitate is formed which obviously consists of achlorinsubstituted cotarnin, while the chlorid of iron is converted intooxy chlorid of iron.

Instead of alcohol some other suitable solvent may be used. Thethuscrystallized chlorid of iron may, for instance, be mixed withcotarnin chlorid and may then be reduced to dryness in cacao and at thecxclu sion of high temperatures. The water of crystallization replacesthe solvent in this instance.

The compound is intended for medicinal and therapeutic uses on accountof its extraordinary styptic or blood-stopping action, both componentsassisting each other 0011- siderably in producing this action. Thestopping of the flow of blood is effected by the cotarnin in consequenceof its action upon the nerves of the ducts, while as regards the chloridof iron the action is brought about by the coagulation of the blood.Hence the action of the cotarnin is but temporary, and in view of theadditional fact that the exclusive use of chlorid of iron entailsdisadvantages, such as an irritating action and a strong yellowcoloration, the double salt described in consequence of its faintlyacidnature shows the combined. action of both components without theirdisadvantages.

What I claim, and desire to secure by Let ters Patent of the UnitedStates, is

1. The process of manufacturing a double salt from chlorid of iron andcotarnin hydrochlorate which consists in reacting on two molecules ofcotarnin hydrochlorate with one molecule of ferric chlorid.

2. The process for manufacturing a double salt from chlorid of iron andcotarnin hydrochlorate which consists in reacting upon a solution of onemolecule of chlorid of iron with a solution of two molecules of cotarninhyboiling temperature, the compound is de-- drochlorate and separatingthe product of In testimony whereof I have signed my the reaction fromthe remaining liquid and name to this specification in the presence ofIO purifying and drying the said product. 1 two subscribing Witnesses.

3. As a new product a crystalline doub e I 5 salt of chlorid of iron andcotarnin hydro- ARNOLD VOSWINKEL' chlorate, soluble in Water and dilutealcohol WVitnesses: and melting at about 104 to 105 centi- WOLDEMARHAUPT, grade. HENRY HASPER.

